Hello, Thanks for introducing me to oxerutins. I did a Google Search on the term an found an abundance of info. Everything that is but where you buy the material. Several places appeared to be sellers but never replied. Apparently oxerutins are effective against the symptoms and even the causes of venous insufficiency. However most of the info stresses they are used in conjunction with wearing compression hose. I did find some interesting info on a medicine called Daflon500 which is derived from citrus. It is mfg. by Servier, a French Co. I found a source of supply. Costs about $1/capsule and the daily dosage starts at 2 and increases from there. The info I have on this substance shows good detail on test results, and an excellent treatise on everything one might want to know about CVI, including a description on the various classes of severity. I intend to deliver this info to my Dr. for his opinion. If you wish I can download this to you. You probably need Adobe Reader capabilities. The literature appears to show Daflon 500 is effective in treating the disease. Again it is used in conjunction with compression therapy. Good luck and Good Health.