You ask how calcium dobesylate is useful in the treatment of venous disease. I do not know. What I do know is that there has been one clinical trial in Germany that evaluated substances such as herbs, vitamins, and new drugs in the treatment of diabetes. Presumeably, there was a positive effect when using calcium dobesylate in lessening thrombosis in retinal vessels of the eye. Whether that effect would extend to lessening venous thrombosis problems is a matter that needs to be studied. Two additional comments are appropriate. In Europe, particularly in Germany, the evaluation, as well as the use, of many agents (including herbs and vitamins) is more extensive than in the United States. With many agents such as nerbal drugs, studies in Europe (and a few in the United States) have yielded mixed results. Even when these drugs are (may be) effective, their effectiveness is likely in persons with mild disease. They are not a substitute for surgery or compressive therapy. However, the may be useful as an adjunct to these therapies. I hope this is useful information for you.